Drosophila melanogaster (a fruit fly) is the poster child for
genetics. Here are a few of its genes. See
FlyNome for stories behind many gene
names, and see
FlyBase for a database of the
bag of marbles - involved in oogenesis,
breathless - involved in development of trachea.
bric à brac
Bride of sevenless (a.k.a. Boss)
buttonhead - regulates segmentation of the head.
capulet (a.k.a. act up)
castor (a.k.a. ming)
Cleopatra - The Cleopatra mutation is lethal only
if Asp is also present.
clueless (a.k.a. abrupt)
daughters against decapentaplegic
deadpan - a pan-neural repressor.
dissatisfaction - involved in many aspects of sexual
double parked - required for DNA replication.
double-time (preferred name: discs overgrown) -
contributes to circadian rhythmicity.
dunce - involved in memory and learning.
exuperantia - an anterior defect mutant named after someone who
fizzy related (preferred name: retina aberrant in
gammy legs (preferred name: pygopus)
gleeful "This gene encodes a C2H2 zinc
finger transcription factor with high sequence similarity to vertebrate
Gli proteins, so we have named the gene gleeful (Gfl)."
[Furlong et al., 2001, Science 293: 1632]
glass bottom boat
gooseberry (a.k.a. gsb-d)
Grunge - a regulator of teashirt.
gypsy - a mobile genetic element.
half pint (preferred name: poly-U-binding splicing
hamlet - named for Hamlet's "to be or not to be"
soliloquy because it affects development of cells descended from the
Drosophila IIB cells. [Science 297: 1355]
hindsight (preferred name: pebbled)
Hippo - Flies with Hippo deleted grow big heads
with folds around the neck.
hobo - a mobile genetic element.
hopscotch - regulates even-skipped gene during
Indy - for "I'm not dead yet"; this mutation makes
the fly live twice as long.
inscuteable (a.k.a. not enough muscle)
ladybird early and ladybird late
lame duck (a.k.a. gleeful)
lethal of scute
lush - mediates responses to alcohols.
Lyra (a.k.a. senseless)
males absent on the first
methuselah - mutants are larger and live longer.
mothers against decapentaplegic
pumilio - regulates Hunchback mRNA.
Seven in absentia
shaggy (a.k.a. zeste white 3)
short stop (a.k.a. groovin, a.k.a. kakapo)
shutdown - needed for normal function of germline
sickle - an apoptosis activator.
snafu - mutants are initially normal but become progressively
more abnormal as they develop.
starry night (a.k.a. flamingo)
stumps (a.k.a. heartbroken)
tinman - the mutant has no heart.
windbeutel - German for "cream puff".
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